Publications

1. A dissociative transition state in Hepatitis Delta Virus ribozyme catalysis.
   Benjamin Weissman, Şölen Ekesan, Hsuan-Chun Lin, Shahbaz Gardezi, Nansheng Li, Timothy J. Giese, Erika McCarthy, Michael E Harris, Darrin M York, and Joseph A Piccirilli, J. Am. Chem. Soc 2023.

2. Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution.
   Jain, N.; Lin, H. C. ; Morgan, C. E.; Harris, M. E.; Tolbert, B. S.
   N.J. and H.-C.L. contributed equally to this work.
   Proc Natl Acad Sci USA 2017.

3. Analysis of the RNA Binding Specificity Landscape of C5 Protein Reveals Structure and Sequence Preferences that Direct RNase P Specificity.
   Lin, H. C.; Zhao, J.; Niland, C. N.; Tran, B.; Jankowsky, E.; Harris, M. E.
   Cell Chem Biol. 2016, 23 (10), 1271-1281.

4. Determination of relative rate constants for in vitro RNA processing reactions by internal competition.
   Lin, H. C., Yandek, L.E., Gjermeni, I. & Harris, M.E.
   Anal. Biochem. 467, 54-61 (2014).

5. Determination of the Specificity Landscape for Ribonuclease P Processing of Precursor tRNA 5’ Leader Sequences.
   Niland, C. N.; Zhao, J.; Lin, H. C.; Anderson, D. R.; Jankowsky, E.; Harris, M.E.
   ACS chemical biology 2016, 11 (8), 2285-92.

6. Alternative substrate kinetics of Escherichia coli ribonuclease P: determination of relative rate constants by internal competition.
   Yandek, L.E., Lin, H.C. ,& Harris, M.E.
   J. Biol. Chem. 288, 8342-8354 (2013).

7. Human plasminogen kringle 1-5 reduces atherosclerosis and neointima formation in mice by suppressing the inflammatory signaling pathway.
   Chang, P.C., Wu, H.L., Lin, H.C., Wang, K.C. & Shi, G.Y.
   J Thromb Haemost 8, 194-201 (2010).

8. Development and Application of High Throughput Methods for Interrogating RNA Binding Specificity.
   Lin, H. C.
   Case Western Reserve University (2017).
   Ph.D. Dissertation.

9. Study the Function of Kringle Proteins in Atherosclerosis.
   Lin, H. C.
   National Cheng Kung University Library, Taiwan (2007)
   Master Thesis.

Conference Talks

1. Kinetic isotope effects on catalysis by the HDV ribozyme-precise determination of isotope ratios using electrospray ionization time-of-flight mass spectrometry
   Hsuan-Chun Lin, Benjamin Weissman, Syed Shahbaz Gardezi, Vernon Anderson, Darrin York, Joseph Piccirilli, Michael Harris
   2018 ACS National meeting New Orleans, March 22-26

2. Next-generation tools for RNA enzymology: Determination of rate and equilibrium constants for large populations of RNA substrate variants using high throughput sequencing
   Hsuan-Chun Lin
   2014 Rustbelt RNA meeting Pittsburgh, October 17-18

Conference Posters

1. Hsuan-Chun Lin, Jing Zhao, Courtney Niland, Brandon Tran, Eckhard Jankowsky and Michael E Harris, Global analyses of RNA binding specificity reveal inde- pendent contributions of sequence and structure. Rustbelt RNA Meeting 2015, Cleveland, Oct 23-24, 2015
2. Hsuan-Chun Lin, Courtney Niland, Jing Zhao, Eckhard Jankowsky and Michael E. Harris, Next-generation tools for RNA enzymology: Determination of rate and equilibrium constants for large populations of RNA substrate variants using high throughput sequencing., 20th Annual Meeting of the RNA Society, 2015
3. Hsuan-Chun Lin, Courtney Niland, Jing Zhao, Eckhard Jankowsky and Michael E. Harris, Next-generation tools for RNA enzymology: Determination of rate and equilibrium constants for large populations of RNA substrate variants using high throughput sequencing., 24th Enzyme Mechanisms Conference, 2015
4. Hsuan-Chun Lin, Ulf-Peter Guenther, Courtney Niland, Vernon Anderson, Eckhard Jankowsky, Michael E. Harris, Next-generation Tools for RNA Enzymology: Determination of Rate and Equilibrium Constants for Large Populations of RNA Substrate Variants Using High Throughput Sequencing., 36th Steenbock Symposium May 22-24, 2014
5. Hsuan-Chun Lin, Ulf-Peter Guenther, Courtney Niland, Vernon Anderson, Eckhard Jankowsky, Michael E. Harris, Next-generation tools for RNA enzymology: Determination of rate and equilibrium constants for large populations of RNA substrate variants using high throughput sequencing., Rustbelt RNA Meeting 2013, Cleveland, Oct 18-19, 2013
6. HC Lin, I Gjermeni, E Jankowsky, M Harris , Determination of the species specific interactions between ribonuclease P protein and substrate RNAs by high-throughput sequencing kinetics (HTS-KIN), 245th ACS National Meeting & Exposition, April 7-11, 2013, New Orleans, Louisiana
7. Lin, RW., Wang, YH., Lai, SC., Lin, HC., Chang, JK., Ho, ML., Wang, GJ., Microporation-based Non-viral Gene Transfer BMP-2 Enhances Repair of Crit- ical Size Bone Defects. Orthopaedic Research Society. (2011)
8. Lin, RW., Wang, YH., Chu, HC., Lai, SC., Lin, HC., Chang, JK., Ho, ML., Wang, GJ. Bone regeneration in critical size defect by hBMSCs mediated BMP- 2 non-viral gene transfer. Orthopaedic Research Society, New Orleans, Louisiana, USA. Mar 6- Mar 9. Abstract ID: ORS2010-2642. (2010)